PICO questions or statements take into account the outcome of a current intervention for a disease or problem and compares it to the outcome of a proposed intervention. PICO questions help health-care providers decide which intervention is the most beneficial to the patient. PICO questions or statements need to contain these elements:
Example: In non-ambulatory patients, (P) does turning the patient (I) compared to pressure mattresses (C ) reduce the risk of pressure ulcers? (O)
You can also add in the element of Time (T) to your PICO question.